Under the category of the OTC/Nutraceutical products are listed the products which are sold without prescription. Members of Farmavita.net are invited to publish their out-license offers in this Category.

Variant of Tumor Necrosis Factor (TNF)-? : Anti-tumor agent acting on Melanoma & Soft Tissue Sarcoma

Popular

Description

Variant of Tumor Necrosis Factor

TNF-α has been clinically proven as a tumor killing agent. M3S is a TNF-α Mutein (a variant of TNF-α) proven to have superior anti-tumor activity and safety compared to natural form. 

Mechanism of action

TNF-α Mutein (a variant of TNF-α) made from amino acids substitution of TNF-α variant which shown the highest cytotoxicity among variants.

Development status

Approved conditionally.

-       Condition : For clinical study only

-       Indication : Melanoma, sarcoma and other 3 cancers (liver cancer, breast cancer, ovary cancer)

Patent information

Patent registered in Korea (Reg. No. 123315 / 185330 / 123291), Germany (Reg. No. DE4404124), France (Reg. No. F.P.2701264), USA (USP5773582), Japan (Reg. No. JP2837344) and UK (GB2275683).

Type of business relationship sought

Out-licensing of cell line to produce M3S (Host cell : E.coli)

Full description

 

Natural TNF-α has known to have tumor killing activity and been studied clinically against cancer patients since late 1980. However, systemic administration of natural TNF-α showed severe adverse reactions. Due to the severe adverse reaction TNF-α treatment has limitation in application.

For production of effective & safe anti-tumor agent derived from TNF-α, a large number of TNF-α variant was produced and a variant with highest cytotoxicity was selected (3S). To eliminate severe toxicity, 3 amino acids of variant were substituted and a part of N-terminal amino acids were deleted (M3S).

M3S has over 10-folds lower toxicity and increased efficacy compared to natural TNF-α. It is for treatment of melanoma and soft tissue sarcoma and other cancers (liver cancer, breast cancer and ovary cancer).

More details

Name Description
Pharma licensing Out-licensing (offer)

Ad details

Ad ID : 602

Advertiser details

Contact Advertiser

Add comment

 
 

Contact form

Sorry, you need to register or login first.

What's wrong with this ad?

Sorry, you need to register or login first.

Add to favourites

Sorry, you need to register or login first.

Advert search

Recent adverts

Start-up pharmaceutical company from South...
175 Views
Member of Farmavita.net is looking to...
288 Views
I want to give process knowhow and NON GMO...
n/a
809 Views
OUT-LICENSING HYBRID DOSSIER OF ALIMEMAZINE...
1066 Views
 Company portfolio: Manufacturing over 100...
1417 Views
Objective: To enter into EU domain procuring...
1195 Views
Objective: To enter into EU domain grabbing a...
949 Views