Variant of Tumor Necrosis Factor (TNF)-? : Anti-tumor agent acting on Melanoma & Soft Tissue Sarcoma

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Description

Variant of Tumor Necrosis Factor


TNF-α has been clinically proven as a tumor killing agent. M3S is a TNF-α Mutein (a variant of TNF-α) proven to have superior anti-tumor activity and safety compared to natural form. 


Mechanism of action


TNF-α Mutein (a variant of TNF-α) made from amino acids substitution of TNF-α variant which shown the highest cytotoxicity among variants.



Development status


Approved conditionally.


-       Condition : For clinical study only


-       Indication : Melanoma, sarcoma and other 3 cancers (liver cancer, breast cancer, ovary cancer)


Patent information


Patent registered in Korea (Reg. No. 123315 / 185330 / 123291), Germany (Reg. No. DE4404124), France (Reg. No. F.P.2701264), USA (USP5773582), Japan (Reg. No. JP2837344) and UK (GB2275683).


Type of business relationship sought


Out-licensing of cell line to produce M3S (Host cell : E.coli)


Full description


 


Natural TNF-α has known to have tumor killing activity and been studied clinically against cancer patients since late 1980. However, systemic administration of natural TNF-α showed severe adverse reactions. Due to the severe adverse reaction TNF-α treatment has limitation in application.


For production of effective & safe anti-tumor agent derived from TNF-α, a large number of TNF-α variant was produced and a variant with highest cytotoxicity was selected (3S). To eliminate severe toxicity, 3 amino acids of variant were substituted and a part of N-terminal amino acids were deleted (M3S).


M3S has over 10-folds lower toxicity and increased efficacy compared to natural TNF-α. It is for treatment of melanoma and soft tissue sarcoma and other cancers (liver cancer, breast cancer and ovary cancer).

More details

Name Description
Pharma licensing Out-licensing (offer)

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