In Vitro Buoyancy and Vitro Dissolution Studies of Famotidine Floating Tablets

Famotidine is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis. The recommended adult oral dosage of famotidine is 20 mg twice daily or 40 mg once daily. The effective treatment of erosive esophagitis requires administration of 20 mg of Famotidine 4 times a day. a conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. The short biological half-life of drug (~2.5-4 hours) also favors development of a sustained release formulation. The present work enumerate to study in vitro buoyancy and dissolution studies of famotidine floating system.

 

IN VITRO BUOYANCY AND VITRO DISSOLUTION STUDIES OF FAMOTIDINE FLOATING TABLETS

 

R. Margret Chandira*; Sahu C. M. ;Jayakar B.Vinayaka Mission’s College of Pharmacy

Vinayaka Missions University, Salem, T.N.

                                                            

ABSTRACT

 

Famotidine is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis. The recommended adult oral dosage of famotidine is 20 mg twice daily or 40 mg once daily. The effective treatment of erosive esophagitis requires administration of 20 mg of Famotidine 4 times a day. a conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. The short biological half-life of drug (~2.5-4 hours) also favors development of a sustained release formulation. The present work enumerate to study in vitro buoyancy and dissolution studies of famotidine floating system.

* Corresponding Author

Deptt. Of Pharmaceutics

Vinayaka Mission’s College of Pharmacy

Salem, T.N.-India

INTRODUCTION

Floating systems are one of the important categories of drug delivery systems with gastric retentive behavior. Drugs that could take advantage of gastric retention include:  furosemide, cyclosporine, allopurinol ciprofloxacin and metformin. Drugs whose solubility is less in the higher pH of the small intestine than the stomach (e.g. chlordiazepoxide and cinnarizine, the drugs prone for degradation in the intestinal pH (e.g. captopril), and the drugs for local action in the stomach (e.g. misoprostol) can be delivered in the form of dosage forms with gastric retention. Antibiotics, catecholamines, sedative, analgesics, anticonvulsants, muscle relaxants, antihypertensive and vitamins can be administered in HBS dosage form.

 

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